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Application of the pharmaceutical compositions of the present invention can be both somatic and local. Administration methods comprise enteral such as oral, sublingual and rectal; local such as through-dermal, intradermal and oculodermal; and parenteral.
Acceptable parenteral methods of administration comprise injections, for example, intravenous, intramuscular, hypodermic injections et cetera, and noninjection methods such as intravaginal and nasal.
Per ocular or per oral administration of the compounds and the pharmaceutical compositions of the present invention is more preferable. In particular, the administration can be carried out in the form of eye drops or tablets, granules, capsules or other pressed or compressed form. When a compound of structure I is administered as a pharmaceutical composition, the compound of structure I should be mixed according to formula with a suitable amount of pharmacologically acceptable solvent or carrier so that to have the appropriate form for administration to a patient.
Liquors like water, and oils including petrolic, animal, vegetative and synthetic such as peanut oil, soybean oil, mineral oil and other similar oils can be used as said pharmacological carriers. Normal saline solution, acacia pitch, gelatin, starch, talc, keratin, colloid silver, urea etc can serve as said pharmacological solvents.
Said composition can also include auxiliary substances, stabilizers, thickeners, lubricant and coloring agents. The compounds and compositions of the present invention can be administered in the form of capsules, tablets, pills, pillets, granules, syrups, elixirs, solutions, ophthalmologic solutions, suspensions, emulsions, suppositories or retarded release substances, or in any other form suitable for administration to a patient.
One of the aspects of the present invention is application of the compounds of structure I and compositions in the form of solutions for per oral and per ocular administration.
Therapeutically justified amount of a compound of Structure I required for treatment of a specific disease or symptom, depends on the nature of disease or symptom and a method of administration and should be determined at consultation with a physician in charge.
The following non-limiting Examples illustrate the preparation and use of the compounds of structure I but should not be understood as limiting the invention as modifications in materials and methods will be apparent to the skilled person.SPIDER-MAN: INTO THE SPIDER-VERSE - Official Trailer (HD)
The following examples should not be construed as limiting the scope of this disclosure. At the age of 1. During the period from 1. We use Vitamin E for a comparison with test antioxidants. Animals received the compounds on a small piece of dried bread before a regular meal, and the control group of animals received the same piece of bread without any compound.
After completing the course of antioxidants the animals were weighed and retested with ophthalmoscope. To avoid human factor in the evaluation of compound effects, the researcher who conducted the ophthalmoscopic examination was not told which of the animals received antioxidants.